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Pbp3 dtt
Publication Date: Research Org.: Brookhaven National Lab.
These enzymes are the targets of β-lactam antibiotics, as their inhibition reduces the structural integrity of the cell wall. The final steps of cell-wall biosynthesis in bacteria are carried out by penicillin-binding proteins (PBPs), whose transpeptidase domains form the cross-links in peptidoglycan chains that define the bacterial cell wall.